Chalcogen bonding mediates the formation of supramolecular helices of azapeptides in crystals
Di Shi, Jinlian Cao, Peimin Weng, Xiaosheng Yan, Zhao Li, Yun‐Bao Jiang
Abstract
To explore whether chalcogen bonding was able to drive the formation of supramolecular helices, alanine-based azapeptides containing a β-turn structure, with a thiophene group, respectively, incorporated in the N- or C-terminus, were employed as helical building blocks. While the former derivative formed a supramolecular M-helix via intermolecular SS chalcogen bonding in crystals, the latter formed P-helix via intermolecular SO chalcogen bonding.
Topics & Concepts
ChalcogenSupramolecular chemistryChemistryIntermolecular forceCrystallographyThiopheneStereochemistryCrystal structureMoleculeOrganic chemistryCrystallography and molecular interactionsSupramolecular Self-Assembly in MaterialsChemical Synthesis and Analysis