Triflylpyridinium as Coupling Reagent for Rapid Amide and Ester Synthesis
Du Chen, Liangxuan Xu, Bowen Ren, Zian Wang, Chao Liu
Abstract
An effective method has been developed to facilitate the synthesis of amides and esters at ambient temperature within 5 min, in which a stable and easily accessible triflylpyridinium reagent is used. Remarkably, this method not only has a wide range of substrate compatibility but also could realize the scalable synthesis of peptide and ester via a continuous flow process. Moreover, excellent chirality retentions are presented during activation of carboxylic acid.
Topics & Concepts
ChemistryReagentAmideCombinatorial chemistryCompatibility (geochemistry)Substrate (aquarium)Chirality (physics)Carboxylic acidOrganic chemistryChemical engineeringChiral symmetryQuantum mechanicsGeologyEngineeringOceanographyQuarkPhysicsNambu–Jona-Lasinio modelChemical Synthesis and AnalysisCarbohydrate Chemistry and SynthesisInnovative Microfluidic and Catalytic Techniques Innovation