Ferroptosis in immune cells: Implications for tumor immunity and cancer therapy
Jianbo Gao, Xiaoling Zhang, Yue Liu, Xu Gu
Abstract
Ferroptosis, an iron-dependent cell death driven by lipid peroxidation, has emerged as a pivotal mechanism in cancer biology with significant therapeutic potential. Immune cells, both innate and adaptive, are integral in detecting and eliminating tumor cells, yet their response is intricately modulated by ferroptosis. While cancer cell ferroptosis stimulates anti-tumor immunity, ferroptosis in immune cells undermines their effectiveness, compromising overall immune surveillance. The intricate crosstalk between ferroptosis and immune responses is pivotal in tumor progression and therapeutic outcomes, shaping both cancer resistance and treatment effectiveness. This review explores the multifaceted relationship between ferroptosis and immune function in cancer, offering insights into how these processes intersect to shape tumor immunity and guide immunotherapy strategies. We highlight cutting-edge research, uncover key molecular mechanisms, and outline promising avenues for future studies and therapeutic interventions in this evolving field.