Circular RNA circSFMBT2 downregulation by HBx promotes hepatocellular carcinoma metastasis via the miR-665/TIMP3 axis
Haohan Liu, Yongcong Yan, Jianhong Lin, Chuanchao He, Hao Liao, Huoming Li, Zhenyu Zhou, Jie Wang, Kai Mao, Zhiyu Xiao
Abstract
. The mechanism of circSFMBT2 was to as a sponge of miR-665, which is a negative regulator of tissue inhibitor of metalloproteinases 3 (TIMP3). However, HBx downregulated circSFMBT2 via the interaction with DExH-box helicase 9 (DHX9), which binds to flanking circRNA-forming introns. In conclusion, circSFMBT2, which is downregulated by HBx, acts as a tumor suppressor to inhibit tumor metastasis through the miR-665/TIMP3 axis. Our study suggests that circSFMBT2 could be a potential prognostic biomarker and therapeutic target for HCC.
Topics & Concepts
HBxCancer researchCircular RNADownregulation and upregulationCarcinogenesisHepatocellular carcinomaOncogeneMetastasismicroRNACancerBiologyGeneTransfectionCell cycleGeneticsCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research