Skeletal muscle mitochondrial dysfunction and muscle and whole body functional deficits in cancer patients with weight loss
Hawley Kunz, John D. Port, Kenton R. Kaufman, Aminah Jatoi, Corey R. Hart, Kevin J. Gries, Ian R. Lanza, Rajiv Kumar
Abstract
To our knowledge, this is the first study to suggest that skeletal muscle mitochondrial deficits are associated with cancer-associated weight loss in humans. Mitochondrial deficits were concurrent with reductions in whole body and skeletal muscle functional capacity. Whether mitochondrial deficits are causal or secondary to cancer-associated weight loss and functional deficits remains to be determined, but this study supports further exploration of mitochondria as a driver of cancer-associated losses in muscle mass and function.
Topics & Concepts
Skeletal muscleMetabolomeMitochondrionCancerBiologyWeight lossEndocrinologyInternal medicineMedicineBiochemistryMetaboliteObesityNutrition and Health in AgingDiet and metabolism studiesMetabolism, Diabetes, and Cancer