Systematic Genetic Interaction Analysis Identifies a Transcription Factor Circuit Required for Oropharyngeal Candidiasis
Norma V. Solis, Rohan S. Wakade, Virginia E. Glazier, Tomye L. Ollinger, Melanie Wellington, Aaron P. Mitchell, Scott G. Filler, Damian J. Krysan
Abstract
The pathology of oral candidiasis has features of biofilm formation, a well-studied process in vitro . Based on that analogy, we hypothesized that the network of transcription factors that regulates in vitro biofilm formation has similarities and differences during oral infection.
Topics & Concepts
FilamentationTranscription factorCandida albicansInfectivityMutantBiofilmMicrobiologyTranscription (linguistics)Corpus albicansIn vitroBiologyChemistryCell biologyGeneticsGeneBacteriaVirusPhilosophyLinguisticsPhysicsOpticsLaserAntifungal resistance and susceptibilityFungal Infections and StudiesOral microbiology and periodontitis research