Design and synthesis of new indole drug candidates to treat Alzheimer’s disease and targeting neuro-inflammation using a multi-target-directed ligand (MTDL) strategy
Phoebe F. Lamie, Maha M. Abdel‐Fattah, John N. Philoppes
Abstract
BuChE active sites, drug-likeness, and ADMET prediction were performed.
Topics & Concepts
AchéChemistryIndole testAcetylcholinesteraseIn vitroDrugPharmacologyDocking (animal)SelectivityBiochemistryEnzymeMedicineCatalysisNursingCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments