Autonomic nervous regulation of cellular processes during subchondral bone remodeling in osteoarthritis
Gundula Rösch, Frank Zaucke, Zsuzsa Jenei‐Lanzl
Abstract
The autonomic nervous system (ANS) with its two major branches, the sympathetic and parasympathetic nervous systems, plays a role in osteoarthritis pathogenesis by influencing bone structure and remodeling. We here review the current knowledge on subchondral bone remodeling with special regard to different bone cell types and underlying mechanisms at the cellular and molecular level. A better understanding of these mechanisms is needed for the development of novel OA treatment strategies targeting the ANS.
Topics & Concepts
Bone remodelingMedicineOsteoarthritisSubchondral boneBone resorptionBone remodeling periodAutonomic nervous systemPathogenesisNeuroscienceCentral nervous systemSympathetic nervous systemNervous systemInflammationPathologyOsteoclastBiologyInternal medicineArticular cartilageBlood pressurePsychiatryReceptorHeart rateAlternative medicinePain Mechanisms and TreatmentsOsteoarthritis Treatment and MechanismsCalpain Protease Function and Regulation