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xTrimoPGLM: unified 100-billion-parameter pretrained transformer for deciphering the language of proteins

Bo Chen, Xingyi Cheng, Li Pan, Yangli‐ao Geng, Jing Gong, Zhi‐Gang She, Zhilei Bei, Xu Tan, Boyan Wang, Xin Zeng, Chi-Ming Liu, Aohan Zeng, Yuxiao Dong, Jie Tang, Le Song

2025Nature Methods44 citationsDOI

Topics & Concepts

Computer scienceComputational biologyTransformerBiologyEngineeringElectrical engineeringVoltageMachine Learning in BioinformaticsGenomics and Phylogenetic StudiesProtein Structure and Dynamics
xTrimoPGLM: unified 100-billion-parameter pretrained transformer for deciphering the language of proteins | Litcius