Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression
Chih‐Hsien Cheng, Chen-Fang Lee, Byoung Chol Oh, Georg J. Furtmüller, Chirag H. Patel, Gerald Brandacher, Jonathan D. Powell
Abstract
Transplant tolerance in the absence of long-term immunosuppression has been an elusive goal for solid organ transplantation. Recently, it has become clear that metabolic reprogramming plays a critical role in promoting T cell activation, differentiation, and function. Targeting metabolism can preferentially inhibit T cell effector generation while simultaneously promoting the generation of T regulatory cells. We hypothesized that costimulatory blockade with CTLA4Ig in combination with targeting T cell metabolism might provide a novel platform to promote the induction of transplant tolerance.
Topics & Concepts
ImmunosuppressionEffectorCell metabolismImmune toleranceReprogrammingBlockadeCell biologyTransplantationT cellFunction (biology)ImmunologyBiologyMetabolismCellImmune systemMedicineReceptorBiochemistryInternal medicineRenal Transplantation Outcomes and TreatmentsImmune Cell Function and InteractionT-cell and B-cell Immunology