The Groebke–Blackburn–Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019–2023)
Cristina Martini, Muhammad Idham Darussalam Mardjan, Andrea Basso
Abstract
The Groebke–Blackburn–Bienaymé (GBB) three-component reaction, discovered in 1998, is a very efficient strategy to assemble imidazo[1,2- a ]-heterocycles starting from amidines, aldehydes and isocyanides. This review aims to exhaustively describe innovative aspects of this reaction achieved during the last five years, and classifies them into five categories: synthetic methods, building blocks, scaffolds, biological activities and physical properties.
Topics & Concepts
ChemistryMaturity (psychological)NanotechnologyPsychologyDevelopmental psychologyMaterials scienceAsymmetric Synthesis and CatalysisCarbohydrate Chemistry and SynthesisSynthetic Organic Chemistry Methods