Palladium-catalyzed regioselective synthesis of B(4,5)- or B(4)-substituted <i>o</i>-carboranes containing α,β-unsaturated carbonyls
Chuyi Zhang, Qian Wang, Song Tian, Jianwei Zhang, Jiaoyi Li, Ling Zhou, Jian Lu
Abstract
With the help of a carboxylic acid directing group, Pd-catalyzed regioselective synthesis of B(4,5)- or B(4)-substituted o-carboranes containing α,β-unsaturated carbonyls has been reported. The -COOH, removed during the course of the reaction, is responsible for controlling the regioselectivity. The desired products could be obtained in moderate to good yields.
Topics & Concepts
RegioselectivityDecarboxylationCatalysisChemistryPalladiumMedicinal chemistryCoupling reactionOrganic chemistryBoron Compounds in ChemistryOrganoboron and organosilicon chemistryRadiopharmaceutical Chemistry and Applications