Alkali metal decorated C<sub>60</sub> fullerenes as promising materials for delivery of the 5-fluorouracil anticancer drug: a DFT approach
Mehdi D. Esrafili, Adnan Ali Khan
Abstract
DFT calculations show the capability of alkali metal (AM = Li, Na, and K) decorated C60 fullerenes to deliver multiple 5-fluorouracil 5FU molecules. The results show 5FU may be protonated to target cancerous tissues, this causes the drug to be realised from the fullerene.
Topics & Concepts
FullereneAlkali metalProtonationAnticancer drugDrugMoleculeDrug deliveryFluorouracilMetalCombinatorial chemistryNanotechnologyMaterials scienceChemistryInorganic chemistryComputational chemistryOrganic chemistryPharmacologyCancerIonMedicineInternal medicineFullerene Chemistry and ApplicationsGraphene research and applicationsBoron and Carbon Nanomaterials Research