AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells
Junqing An, Ye Ding, Changjiang Yu, Jian Li, Shaojin You, Zhixue Liu, Ping Song, Ming‐Hui Zou
Abstract
). Our results suggest that AMPKα1 activation promotes tumor growth by maintaining FOXP3 stability in tumor-infiltrating Treg cells and that selective inhibition of AMPK in Treg cells might be an effective anti-tumor therapy.
Topics & Concepts
AMPKFOXP3Protein kinase ACancer researchImmune systemAMP-activated protein kinaseCell biologyTumor microenvironmentBiologyChemistryKinaseImmunologyImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmune cells in cancer