Heart failure with preserved ejection fraction diminishes peripheral hemodynamics and accelerates exercise-induced neuromuscular fatigue
Joshua C. Weavil, Taylor S. Thurston, Thomas J. Hureau, Jayson R. Gifford, P. A. Kithas, Ryan M. Broxterman, Amber D. Bledsoe, Jose Nativí, Russell S. Richardson, Markus Amann
Abstract
The susceptibility to neuromuscular fatigue during exercise is substantially exaggerated in individuals with heart failure with a preserved ejection fraction. The faster rate of fatigue development is associated with the compromised peripheral hemodynamic response characterizing these patients during exercise. Given the role of neuromuscular fatigue as a factor limiting exercise, this impairment likely accounts for a significant portion of the exercise intolerance typical for this population.
Topics & Concepts
Heart failureCardiologyEjection fractionHemodynamicsMedicinePeripheralInternal medicineExercise intoleranceHeart ratePopulationLimitingPhysical medicine and rehabilitationBlood pressureEnvironmental healthMechanical engineeringEngineeringCardiovascular and exercise physiologyMuscle activation and electromyography studiesHeart Rate Variability and Autonomic Control