Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway
Fei Ma, Hao Hu, Xiaoyan Gao, Yao Cai, Jialiang Zhou, Puping Liang, Junjian Lv, Qiuming He, Congcong Shi, Dandan Hu, Bowei Chen, Lixin Zhu, Xin Xiao, Sitao Li
Abstract
These results demonstrate that melatonin-induced activation of AMPK/SIRT1 signaling regulates the balance between Th17 and Treg cells and that therapeutic strategies targeting the Th17/Treg balance via the AMPK/SIRT1 pathway might be beneficial for the treatment of NEC.
Topics & Concepts
MelatoninFOXP3Necrotizing enterocolitisAMPKImmunologyMedicineIL-2 receptorInternal medicineEndocrinologyBiologyT cellImmune systemCell biologyProtein kinase AKinaseInfant Nutrition and HealthCircadian rhythm and melatoninDigestive system and related health