Asymmetric Reductive Amination with Pinacolborane Catalyzed by Chiral SPINOL Borophosphates
Zhenwei Wu, Hualing He, Minglei Chen, Linfei Zhu, Weitao Zheng, Yang Cao, Jon C. Antilla
Abstract
The catalytic asymmetric reductive amination of ketones with pinacolborane employing chiral SPINOL-derived borophosphates as catalysts has been realized. A series of chiral amine derivatives bearing multiple functional groups were obtained in good to excellent yields and enantioselectivities (up to 97% yield, 98% ee) under mild reaction conditions. Moreover, the synthetic applicability of the established method has been demonstrated by the asymmetric synthesis of (R)-Fendiline.
Topics & Concepts
ChemistryAminationYield (engineering)CatalysisReductive aminationAmine gas treatingOrganic chemistryCombinatorial chemistryMaterials scienceMetallurgyAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisAsymmetric Synthesis and Catalysis