Ruthenium-catalysed synthesis of chiral exocyclic allylic alcohols <i>via</i> chemoselective transfer hydrogenation of 2-arylidene cycloalkanones
Kaili Zhang, Qixing Liu, Renke He, Danyi Chen, Zhangshuang Deng, Nianyu Huang, Haifeng Zhou
Abstract
An asymmetric transfer hydrogenation of 2-arylidene four-, five-, six-, and seven-membered cycloalkanones under mild conditions has been performed. Various chiral exocyclic allylic alcohols were obtained by an exclusive reduction of CO bonds.
Topics & Concepts
Allylic rearrangementTransfer hydrogenationChemistryDouble bondRutheniumOrganic chemistryMedicinal chemistryCatalysisAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisCarbon dioxide utilization in catalysis