Regio- and stereoselective synthesis of thiazoline derivatives <i>via</i> the thioketene-induced ring expansion of aziridines
Qiuyue Wu, Jiaxi Xu
Abstract
tandem ring cleavage and formation through intimate ion-pair intermediates after nucleophilic addition of aziridines to thioketenes generated from 4-substituted 1,2,3-thiadiazoles in the presence of a base.
Topics & Concepts
ChemistryRing (chemistry)AziridineIntramolecular forceStereoselectivityStereochemistryTandemThiazolineCleavage (geology)NucleophileNucleophilic substitutionMedicinal chemistryOrganic chemistryCatalysisFracture (geology)Geotechnical engineeringComposite materialEngineeringMaterials scienceSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques