Ni-Catalyzed Reductive Antiarylative Cyclization of Alkynones
Zhijun Zhou, Wenfeng Liu, Wangqing Kong
Abstract
A new catalyst system for the antiarylative cyclization of alkynones and aryl halides through a reductive cross-coupling strategy is developed. The transformation proceeds smoothly in the absence of organometallic reagents and features high functional group tolerance. This method provides an effective platform to access a wide variety of synthetically useful endocyclic tetrasubstituted allylic alcohols in a stereoselective manner.
Topics & Concepts
ChemistryAllylic rearrangementReagentHalideCatalysisArylCombinatorial chemistryFunctional groupStereoselectivityTransformation (genetics)Reductive eliminationOrganic chemistryBiochemistryAlkylGenePolymerCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis