Three-component synthesis of<i>N</i>-naphthyl pyrazoles<i>via</i>Rh(<scp>iii</scp>)-catalyzed cascade pyrazole annulation and Satoh–Miura benzannulation
Demao Chen, Liyun Zhou, Yunyun Liu, Jie‐Ping Wan
Abstract
The reactions of enaminones, hydrazine hydrochlorides and internal alkynes for the synthesis of N -naphthyl pyrazoles are achieved via Rh( iii ) catalysis, representing the first three-component Satoh–Miura benzannulation.
Topics & Concepts
PyrazoleChemistryAnnulationCatalysisRing (chemistry)Hydrazine (antidepressant)Combinatorial chemistryCascade reactionComponent (thermodynamics)CascadeArylTandemMedicinal chemistryRhodiumStereochemistryOrganic chemistryMaterials scienceChromatographyPhysicsAlkylComposite materialThermodynamicsCatalytic C–H Functionalization MethodsSynthesis and Characterization of PyrrolesSulfur-Based Synthesis Techniques