Different Nanotechnology Approaches for Ciprofloxacin Delivery Against Multidrug-Resistant Microbes
Ashagrachew Tewabe Yayehrad, Gebremariam Birhanu Wondie, Tesfa Marew
Abstract
Ashagrachew Tewabe Yayehrad,1,2 Gebremariam Birhanu Wondie,1 Tesfa Marew1 1Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, EthiopiaCorrespondence: Ashagrachew Tewabe Yayehrad, Tel +251912960525, Email [email protected]: The percentages of organisms exhibiting antimicrobial resistance, especially resistance to multiple antibiotics, are incessantly increasing. Studies investigated that many bacteria are being resistant to ciprofloxacin. This review addresses the current knowledge on nano-based ciprofloxacin delivery approaches to improve its effectiveness and overcome the resistance issues. Ciprofloxacin delivery can be modified by encapsulating with or incorporating in different polymeric nanoparticles such as chitosan, PLGA, albumin, arginine, and other organic and inorganic nanostructure systems. Most of these nano-approaches are promising as an alternative strategy to improve the therapeutic effectiveness of ciprofloxacin in the future.Keywords: antimicrobial resistance, ciprofloxacin, ciprofloxacin resistance, nanotechnology