Probiotics Mucoadhesion: Improved Gastric Acid Resistance and Adhesive Colonization of Probiotics by Mucoadhesive and Intestinal Targeted Konjac Glucomannan Microspheres (Adv. Funct. Mater. 35/2020)
Ying Liu, Bin Liu, Dan Li, Yulin Hu, Liang Zhao, Ming Zhang, Shaoyang Ge, Jie Pang, Yixuan Li, Ran Wang, Pengjie Wang, Yutao Huang, Jing Huang, Jie Bai, Fazheng Ren, Yuan Li
Abstract
In article number 2001157, Fazheng Ren, Yuan Li, and co-workers demonstrate an intestinal responsive delivery system for improving the viability of probiotics in gastrointestinal conditions using modified Konjac glucomannan. The delivered probiotics survive under gastric conditions and responsively release in the intestine. Then, disintegrated polysaccharides function as a bridge, promoting the adhesion of probiotics to a mucus network, and prolonging their colonization effectively.
Topics & Concepts
MucoadhesionMucusMaterials scienceAdhesionMicrosphereColonizationGlucomannanMicrobiologyGastric acidDrug deliveryNanotechnologyChemical engineeringMedicineGastroenterologyFood scienceComposite materialStomachDrug carrierBiologyEcologyEngineeringProbiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology