FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice
Wenyan Bo, Yixuan Ma, Lili Feng, Mengyuan Yu, Lili Zhang, Mengxin Cai, Wei Song, Yue Xi, Zhenjun Tian
Abstract
FGF21 activated FGFR1/PI3K/AKT/VEGF signaling pathway mediated angiogenesis in MI mice. FGF21 deficiency attenuated aerobic exercise-induced cardiac angiogenesis in MI mice. FGF21/FGFR1/PI3K/AKT/VEGF signal played an important role in aerobic exercise to promote myocardial angiogenesis and improved cardiac function.
Topics & Concepts
AngiogenesisProtein kinase BPI3K/AKT/mTOR pathwayFibroblast growth factorEndocrinologyCardiac function curveInternal medicineFGF21Vascular endothelial growth factorKnockout mouseMedicineBiologySignal transductionCell biologyReceptorHeart failureVEGF receptorsFibroblast Growth Factor ResearchKruppel-like factors researchCancer, Hypoxia, and Metabolism