Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity
Nova O. Dora, Edith Blackburn, Jessica E. Boles, George T. Williams, Lisa J. White, Scarlett E. G. Turner, Joanne Hothersall, Trevor Askwith, Jack A. Doolan, Daniel P. Mulvihill, Michelle D. Garrett, Jennifer R. Hiscock
Abstract
either agent alone. This work provides the first evidence that SSAs interact with and permeate cancer cell membranes and enhance the cytotoxic activity of a chemotherapeutic drug in human cancer cells.
Topics & Concepts
Supramolecular chemistryNanoscopic scaleCisplatinAmphiphileChemistryEnhancerNanotechnologyCombinatorial chemistryMaterials scienceOrganic chemistryBiochemistryMoleculeMedicineInternal medicineChemotherapyGenePolymerGene expressionCopolymerSupramolecular Self-Assembly in MaterialsDendrimers and Hyperbranched PolymersNanoplatforms for cancer theranostics