SCRN1 confers hepatocellular carcinoma resistance to ferroptosis by stabilizing GPX4 via STK38-mediated phosphorylation
Yijie Tao, Shulei Yin, Kai Wei, Liyuan Zhao, Yani Cui, Chunzhen Li, Yunyang Wu, Panpan Hu, Shenhui Yin, Likun Cui, Yunyan Zhang, Yixian He, Shu Yu, Jie Chen, Shaoteng Lu, Guifang Qiu, Mengqi Song, Siqi Yang, Qianshan Hou, Yiquan Xue, Chen Qian, Sheng Xu, Yizhi Yu, Zui Zou
Topics & Concepts
GPX4PhosphorylationCancer researchHepatocellular carcinomaLipid peroxidationKinaseHeat shock proteinChemistryDownregulation and upregulationPhospholipid-hydroperoxide glutathione peroxidaseProtein kinase AHepatic carcinomaProgrammed cell deathMechanism (biology)Cell culturep38 mitogen-activated protein kinasesCell biologySignal transductionGlutathioneCellPeroxidaseFerroptosis and cancer prognosisRNA modifications and cancerCancer-related molecular mechanisms research