Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate
Søren W. Svenningsen, Rikki Franklin Frederiksen, Claire Counil, Mario Ficker, Jørgen J. Leisner, Jørn B. Christensen
Abstract
Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.
Topics & Concepts
ConjugateDendrimerCiprofloxacinAntimicrobialAntibioticsMicrobiologyChemistryBacteriaCombinatorial chemistryGram-negative bacteriaCovalent bondBiologyBiochemistryOrganic chemistryEscherichia coliMathematical analysisGeneticsGeneMathematicsDendrimers and Hyperbranched PolymersAdvanced biosensing and bioanalysis techniquesClick Chemistry and Applications