Exosomes derived from mycobacterium tuberculosis-infected MSCs induce a pro-inflammatory response of macrophages
Min Liu, Zaiguo Wang, Shaolei Ren, Hongli Zhao
Abstract
, and exosomes isolated from Exo-MSCs-M.tb-treated mice could also promote the pro-inflammatory response. Taken together, these results indicate that Exo-MSCs-M.tb induced the pro-inflammatory response of macrophages through TLRs signaling. This study provides new insight into the potential of MSCs-derived exosomes for the treatment of TB.
Topics & Concepts
MicrovesiclesMycobacterium tuberculosisInflammatory responseTuberculosisImmunologyMicrobiologyMacrophageVirologyMycobacteriumInflammationMedicineBiologyIn vitroPathologymicroRNABiochemistryGeneExtracellular vesicles in diseaseMicroRNA in disease regulationPhagocytosis and Immune Regulation