Bone marrow hematopoiesis drives multiple sclerosis progression
Kaibin Shi, Handong Li, Ting Chang, Wenyan He, Ying Kong, Caiyun Qi, Ran Li, Huachen Huang, Zhibao Zhu, Pei Zheng, Zhe Ruan, Jie Zhou, Fu‐Dong Shi, Qiang Liu
Abstract
monocytes that invade the CNS. We found that myelin-reactive T cells preferentially migrate into the bone marrow compartment in a CXCR4-dependent manner. This aberrant bone marrow myelopoiesis involves the CCL5-CCR5 axis and augments CNS inflammation and demyelination. Our study suggests that targeting the bone marrow niche presents an avenue to treat MS and other autoimmune disorders.
Topics & Concepts
MyelopoiesisBone marrowExperimental autoimmune encephalomyelitisBiologyHaematopoiesisImmunologyMultiple sclerosisMyeloidProgenitor cellStem cellCell biologyImmune cells in cancerHematopoietic Stem Cell TransplantationImmunotherapy and Immune Responses