Prevention of radiotherapy-induced pro-tumorigenic microenvironment by SFK inhibitors
Yong June Choi, Myung Jun Kim, Young Ju Lee, Munkyung Choi, Wan Seob Shim, Miso Park, Yong‐Chul Kim, Keon Wook Kang
Abstract
Reshaping the tissue microenvironment by targeting SFKs is a potential strategy for preventing metastasis and recurrence following radiotherapy. The finding that clinically imperceptible damage can trigger a pro-tumorigenic microenvironment suggests the need for combining SFK-targeted inhibitors with radiotherapy.
Topics & Concepts
Tumor microenvironmentCancer researchRadiation therapyChemistryMedicineInternal medicineTumor cellsCell Adhesion Molecules ResearchGalectins and Cancer BiologyCancer Immunotherapy and Biomarkers