The Colorectal Cancer Gut Environment Regulates Activity of the Microbiome and Promotes the Multidrug Resistant Phenotype of ESKAPE and Other Pathogens
Matthew T. F. Lamaudière, Ramesh Arasaradnam, Gareth D. Weedall, Igor Y. Morozov
Abstract
, can be regulated by specific environmental stresses of the gut, including organic and inorganic acid pressure in a health-dependent manner. This work advances the field of microbiology in the context of disease, showing, for the first time, that colorectal cancer regulates activity of gut microorganisms and that specific gut environmental pressures can modulate their antibiotic resistance determinants expression.
Topics & Concepts
BiologyGut floraMicrobiomePhenotypeColorectal cancerGeneMicrobiologyPopulationGeneticsCancerImmunologyMedicineEnvironmental healthGut microbiota and healthClostridium difficile and Clostridium perfringens researchDrug Transport and Resistance Mechanisms