Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2
Zirong Chen, Junhong Wang, Peng Peng, Guohao Liu, Minhai Dong, Xiaolin Zhang, Yang Zhang, Xue Yang, Li‐Jun Wan, Xiang Wang, Suojun Zhang, Bin Zhang, Qiuxia Wu, Xingjiang Yu, Feng Wan
Abstract
TGFBI plays a crucial role in maintaining the stem cell properties of GSCs in the hypoxic microenvironment. Targeting the TGFBI/EphA2 axis emerges as a promising and innovative strategy for GBM treatment, with the potential to improve the clinical outcomes of patients.
Topics & Concepts
GliomaHypoxia (environmental)EPH receptor A2Stem cellChemistryCancer researchCell biologyBiologyNeuroscienceReceptorBiochemistryOxygenOrganic chemistryReceptor tyrosine kinaseAxon Guidance and Neuronal SignalingCancer, Hypoxia, and MetabolismNeuroblastoma Research and Treatments