Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy
Menglu Chen, Chun‐Gu Hong, Tao Yue, Hongmin Li, Ran Duan, Wenbao Hu, Jia Cao, Zhen‐Xing Wang, Chun‐Yuan Chen, Xiong‐Ke Hu, Ben Wu, Haoming Liu, Yi‐Juan Tan, Jianghua Liu, Zhong‐Wei Luo, Yan Zhang, Shan‐Shan Rao, Mingjie Luo, Hao Yin, Yiyi Wang, Kun Xia, Siyuan Tang, Hui Xie, Zhengzhao Liu
Abstract
Our study suggests that using miR-331-3p and miR-9-5p, along with autophagic activity and amyloid plaques may distinguish early versus late stage of AD for more accurate and timely diagnosis. Additionally, we further provide a possible new therapeutic strategy for AD patients by inhibiting miR-331-3p and miR-9-5p and enhancing autophagy.
Topics & Concepts
AutophagyBECN1Sequestosome 1MicrogliaMorris water navigation taskAlzheimer's diseaseMedicineAmyloid betaDownregulation and upregulationCD68PathologyCancer researchBiologyImmunohistochemistryDiseaseInternal medicineInflammationHippocampusApoptosisGeneBiochemistryAutophagy in Disease and TherapyAlzheimer's disease research and treatmentsMicroRNA in disease regulation