Injectable <i>in situ</i> gelling methylcellulose-based hydrogels for bone tissue regeneration
Lorenzo Bonetti, Silvia Borsacchi, Alessandra Soriente, Alberto Boccali, Lucia Calucci, Maria Grazia Raucci, Lina Altomare
Abstract
biological characterization revealed the beneficial impact of CaP and CaPGO, indicating their potential in promoting cell adhesion, proliferation and osteogenic differentiation. Remarkably, the addition of GO, which is very attractive for its bioactive properties, did not negatively affect the injectability of the hydrogel nor the mineralization process, but had a positive impact on cell growth and osteogenic differentiation on both pre-differentiated and undifferentiated cells. Overall, the proposed formulations represent potential candidates for use as IBSs for application in bone regeneration both under physiological and pathological conditions.