The cardioprotective effect persisting during recovery from cold acclimation is mediated by the β<sub>2</sub>-adrenoceptor pathway and Akt activation
Veronika Tibenská, Aneta Marvanová, Barbara Elsnicová, Lucie Hejnová, Pavel Vebr, Jiřı́ Novotný, František Kolář, Olga Nováková, Jitka Žurmanová
Abstract
Cardioprotective effect of cold acclimation and that persisting for 2 wk after recovery engage in different mechanisms. The β 2 -adrenoceptor/G i pathway and Akt are involved only in the mechanism of infarct size-limiting effect occurring during the recovery phase. GSK-3β translocated from the Z-line to the H-zone of sarcomeres by cold acclimation returns back to the original position after the recovery phase. The results provide new insights potentially useful for the development of cardiac therapies.
Topics & Concepts
AcclimatizationProtein kinase BChemistryEndocrinologyInternal medicinePharmacologyBiologySignal transductionMedicineCell biologyEcologyCardiac Ischemia and ReperfusionAdipose Tissue and MetabolismAnesthesia and Neurotoxicity Research