Griffithsin with A Broad-Spectrum Antiviral Activity by Binding Glycans in Viral Glycoprotein Exhibits Strong Synergistic Effect in Combination with A Pan-Coronavirus Fusion Inhibitor Targeting SARS-CoV-2 Spike S2 Subunit
Yanxing Cai, Wei Xu, Chenjian Gu, Xia Cai, Di Qu, Lu Lu, Youhua Xie, Shibo Jiang
Topics & Concepts
VirologyCoronavirusGlycoproteinSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)GlycanIn vitroViral entryLipid bilayer fusionCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus2019-20 coronavirus outbreakInhibitory postsynaptic potentialChemistryBiologyMedicineVirusViral replicationMolecular biologyBiochemistryInfectious disease (medical specialty)PathologyNeuroscienceDiseaseOutbreakPharmacological Effects of Natural CompoundsImmune Response and InflammationToxin Mechanisms and Immunotoxins