Effects of the IDH1 R132H Mutation on the Energy Metabolism: A Comparison between Tissue and Corresponding Primary Glioma Cell Cultures
Lennard J. M. Dekker, Cassandra Verheul, Nicky Wensveen, William P. J. Leenders, Martine L.M. Lamfers, Sieger Leenstra, Theo M. Luider
Abstract
microenvironment, such as three-dimensional cell co-cultures or organotypic multicellular spheroid models, need to be developed and investigated.
Topics & Concepts
Isocitrate dehydrogenaseGliomaIn vivoBiologyCell cultureCancer researchGlycolysisIDH1Glutamate dehydrogenaseMetabolismAnaerobic glycolysisCellBiochemistryTumor microenvironmentGlutamate receptorEnzymeMutationGeneticsTumor cellsReceptorGeneGlioma Diagnosis and TreatmentCancer, Hypoxia, and MetabolismMedical Imaging Techniques and Applications