Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow’s Disease
Aniek L. van Wijngaarden, Boudewijn P. T. Kruithof, Tommaso Vinella, Daniela Q.C.M. Barge‐Schaapveld, Nina Ajmone Marsan
Abstract
Degenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency (FED) and Barlow's disease. The aim of this review was to describe the main histological, clinical and echocardiographic features of patients with FED and Barlow's disease, highlighting the differences in diagnosis, risk stratification and patient management, but also the still significant gaps in understanding the exact pathophysiology of these two phenotypes.
Topics & Concepts
CardiologyInternal medicineMitral valveMedicineDiseaseCardiac Valve Diseases and TreatmentsCardiac Structural Anomalies and RepairCardiomyopathy and Myosin Studies