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Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway

Jing Qin, Xia Sun, Yingang Ma, Yahong Cheng, Qiushuang Ma, Weiqiang Jing, Sifeng Qu, Lei Liu

2021Bioorganic & Medicinal Chemistry24 citationsDOI

Topics & Concepts

PI3K/AKT/mTOR pathwayChemistryTriple-negative breast cancerProtein kinase BApoptosisCancer researchCell growthCancer cellCell cyclePharmacologyBreast cancerCancerBiochemistryBiologyInternal medicineMedicineSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activityNanoplatforms for cancer theranostics
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway | Litcius