Catalytic Enantioselective Synthesis of 2,3′-Bis(indolyl)methanes Bearing All-Carbon Quaternary Stereocenters via 2-Indole Imine Methides
Zhengyu Han, Wenlong Wang, Han Zhuang, Jie Wang, Jie Wang, Cheng Wang, Jianhao Wang, Jianhao Wang, Hai Huang, Jianwei Sun
Abstract
An organocatalytic enantioselective formal hydroarylation of 2-vinyl indoles for the preparation of enantioenriched 2,3'-bis(indolyl)methanes bearing an all-carbon quaternary stereocenter is described. This reaction features mild conditions, low catalyst loading, excellent efficiency and enantioselectivity. The obtained products showed promising anticancer activity.
Topics & Concepts
StereocenterEnantioselective synthesisChemistryImineCatalysisIndole testQuaternary carbonOrganocatalysisCarbon fibersOrganic chemistryCombinatorial chemistryMaterials scienceComposite numberComposite materialSynthesis of Indole DerivativesChemical Synthesis and ReactionsAxial and Atropisomeric Chirality Synthesis