A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization
Chen Zhao, Thalyta X. Medeiros, Richard J. Sové, Brian H. Annex, Aleksander S. Popel
Abstract
condition of peripheral arterial disease to evaluate strategies that can potentially induce therapeutic macrophage repolarization. Our model is a key step toward the future development of a network-centric, comprehensive "virtual macrophage" simulation platform.
Topics & Concepts
Macrophage polarizationIn silicoComputational modelComputational biologyComputer sciencePhenotypeBiological systemPopulationSystems biologyMacrophageBiologyNeuroscienceIn vitroArtificial intelligenceMedicineGeneticsGeneEnvironmental healthImmune cells in cancerEpigenetics and DNA MethylationSingle-cell and spatial transcriptomics