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Physiologically based pharmacokinetic combined JAK2 occupancy modelling to simulate PK and PD of baricitinib with kidney transporter inhibitors and in patients with hepatic/renal impairment

Zhongjian Wang, Wei Liu, Xueyan Li, Hong-Jiao Chen, Dongying Qi, Fulu Pan, Huining Liu, Shuang Yu, Bowen Yi, Guopeng Wang, Yang Liu

2022Regulatory Toxicology and Pharmacology11 citationsDOI

Topics & Concepts

Physiologically based pharmacokinetic modellingProbenecidPharmacokineticsPharmacologyTransporterPharmacodynamicsKidneyChemistryMedicineUrologyInternal medicineBiochemistryGeneMyeloproliferative Neoplasms: Diagnosis and TreatmentChronic Myeloid Leukemia TreatmentsDrug Transport and Resistance Mechanisms
Physiologically based pharmacokinetic combined JAK2 occupancy modelling to simulate PK and PD of baricitinib with kidney transporter inhibitors and in patients with hepatic/renal impairment | Litcius