Protection and Isolation of Bioorthogonal Metal Catalysts by Using Monolayer‐Coated Nanozymes
Xianzhi Zhang, Stefano Fedeli, S. Gopalakrishnan, Rui Huang, Aarohi Gupta, David C. Luther, Vincent M. Rotello
Abstract
We demonstrate here the protection of biorthogonal transition metal catalysts (TMCs) in biological environments by using self-assembled monolayers on gold nanoparticles (AuNPs). Encapsulation of TMCs in this hydrophobic environment preserves catalytic activity in presence of pH conditions and complex biological media that would deactivate free catalyst. Significantly, the protection affords by these nanozymes extends to isolation of the catalyst active site, as demonstrated by the independence of rate over a wide pH range, in strong contrast to the behavior of the free catalyst.
Topics & Concepts
CatalysisMonolayerChemistryBioorthogonal chemistryTransition metalNanoparticleNanotechnologyCombinatorial chemistryColloidal goldChemical engineeringPhotochemistryOrganic chemistryMaterials scienceClick chemistryBiochemistryEngineeringAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesNanocluster Synthesis and Applications