Rhenium(I)-Catalyzed C-Methylation of Ketones, Indoles, and Arylacetonitriles Using Methanol
Sujan Shee, Sabuj Kundu
Abstract
) system was developed for the C-methylation reactions utilizing methanol and base, following the borrowing hydrogen strategy. Diverse ketones, indoles, and arylacetonitriles underwent mono- and dimethylation selectively up to 99% yield. Remarkably, tandem multiple methylations were also achieved by employing this catalytic system.
Topics & Concepts
RheniumMethanolCatalysisMethylationYield (engineering)TandemChemistryMedicinal chemistryBase (topology)HydrogenOrganic chemistryCombinatorial chemistryBiochemistryMaterials scienceComposite materialMetallurgyMathematicsMathematical analysisGeneAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysisCatalytic C–H Functionalization Methods