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Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

Ashley J. Russo, Swathy O. Vasudevan, Santiago P. Méndez‐Huergo, P. Hima Kumari, Antoine Ménoret, Shivalee Duduskar, Chengliang Wang, Juan M. Pérez Sáez, Margaret M. Fettis, Chuan Li, Renjie Liu, Arun Wanchoo, Karthik Chandiran, Jianbin Ruan, Sivapriya Kailasan Vanaja, Michael Bauer, Christoph Sponholz, Gregory A. Hudalla, Anthony T. Vella, Beiyan Zhou, Sachin D. Deshmukh, Gabriel A. Rabinovich, Vijay Rathinam

2021Nature Immunology127 citationsDOIOpen Access PDF

Topics & Concepts

PyroptosisNecroptosisInflammationGalectin-1Galectin-3Cell biologyGalectinProgrammed cell deathLipopolysaccharideProinflammatory cytokineCytosolBiologyIntracellularImmune systemImmunologyApoptosisInflammasomeBiochemistryEnzymeInflammasome and immune disordersGalectins and Cancer BiologyAmoebic Infections and Treatments
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin | Litcius