New Chiral BINOL‐Based Phosphates for Enantioselective [Au(I)]‐Catalyzed Dearomatization of β‐Naphthols with Allenamides
Riccardo Pedrazzani, Juzeng An, Magda Monari, Marco Bandini
Abstract
Abstract New chiral BINOL‐based phosphate counterions have been synthesized, fully characterized, and employed in the enantioselective gold‐catalyzed dearomatization of β‐naphthols with allenamides. A range of densely functionalized C1‐allylated naphthalenones were realized under mild conditions and high levels of chemo‐, regio‐ and stereoselectivity ( ee up to 95 %).
Topics & Concepts
Enantioselective synthesisChemistryStereoselectivityCatalysisCounterionPhosphateCombinatorial chemistryOrganic chemistryOrganocatalysisIonCatalytic Alkyne ReactionsTraditional and Medicinal Uses of AnnonaceaeChemical synthesis and alkaloids