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Identifying the Key Photosensitizing Factors over Metal–Organic Frameworks for Selective Control of <sup>1</sup> O <sub>2</sub> and O <sub>2</sub> ⋅ <sup>−</sup> Generation

Xiaoliang Ma, Lihua Ma, Song Guo, Zhiming Zhang, Tong‐Bu Lu

2025Angewandte Chemie International Edition31 citationsDOIOpen Access PDF

Abstract

Abstract The reaction pathway, product selectivity and catalytic efficiency of photo‐oxidation are highly dependent on the specific reactive oxygen species (ROS), such as singlet oxygen ( 1 O 2 ) and superoxide (O 2 ⋅ − ), generated via the sensitization of O 2 by photosensitizers. Studies on uncovering the role of photosensitizing factors on the selective control of 1 O 2 and O 2 ⋅ − generation are significant but remain underexplored. Here, we constructed a photosensitizing metal–organic framework molecular platform (UiO‐1–UiO‐4) by elaborately engineering Ir(III) complex ligands with pyrenyl group for modulating photosensitizing factors and elucidating their impact on ROS generation. Impressively, the ratios of 1 O 2 and O 2 ⋅ − generation varied from 0 : 100 for UiO‐1 to 94 : 6 for UiO‐4 by modulating photosensitizing factors. UiO‐2 and UiO‐4 were respectively immobilized in a continuous‐flow reactor, achieving gram‐scale photosynthesis of phenol and juglone with high purity (&gt;94 %) via O 2 ⋅ − and 1 O 2 pathway, respectively. Investigations reveal that UiO‐4 with ligand localized excited state and long excited state lifetime contributed to triggering energy transfer to afford 1 O 2 , whereas UiO‐1 with charge‐transfer state and negative reduction potential facilitates charge transfer to produce O 2 ⋅ − . This work offers a novel insight into regulating ROS generation by modulating the photosensitizing factors at the molecular level.

Topics & Concepts

ChemistrySinglet oxygenReactive oxygen speciesPhotochemistryElectron transferLigand (biochemistry)CatalysisOxygenCombinatorial chemistryOrganic chemistryBiochemistryReceptorAdvanced Nanomaterials in CatalysisMetal-Organic Frameworks: Synthesis and ApplicationsAdvanced Photocatalysis Techniques