Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis
Bonah Kim, Hee Young Kim, Bo Ruem Yoon, Jina Yeo, Ji In Jung, Kyung‐Sang Yu, Hyeon Chang Kim, Su‐Jin Yoo, Jin Kyun Park, Seong Wook Kang, Won‐Woo Lee
Abstract
expression correlated with more severe RA clinical parameters, suggesting that Zip8-mediated zinc influx is related to inflammatory conditions. These results provide insight into the role of cytoplasmic, bioavailable zinc in the metabolic reprogramming of human monocytes and macrophages in inflammatory responses.
Topics & Concepts
mTORC1Cell biologyImmune systemGlycolysisP70-S6 Kinase 1ZincKinaseChemistryPhosphorylationCancer researchBiologySignal transductionBiochemistryImmunologyMetabolismPI3K/AKT/mTOR pathwayOrganic chemistryTrace Elements in HealthHeavy Metal Exposure and ToxicityIron Metabolism and Disorders