Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors
Yuanyuan Wang, Hao Ma, Jiaxuan Huang, Zhengguang Yao, Jianqiang Yu, Wannian Zhang, Lichao Zhang, Zhibin Wang, Chunlin Zhuang
Topics & Concepts
NecroptosisChemistryRIPK1Programmed cell deathPharmacologyIn vivoNatural productApoptosisBiochemistryMedicineBiologyBiotechnologyCell death mechanisms and regulationHeat shock proteins researchMitochondrial Function and Pathology