Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner
Meng Chen, Menghang Wang, Xue-Gang Shen, Hao Liu, Yuyuan Zhang, Jinmei Peng, Fandan Meng, Tong-Yun Wang, Yuanzhe Bai, Mingxia Sun, Zhi‐Jun Tian, Xin Yin, Xuehui Cai, Yan‐Dong Tang
Abstract
, Δfurin PRV virulence was significantly attenuated in mice. Therefore, NRP1 is an important host factor for PRV, and NRP1 may be a potential target for antiviral drug development.
Topics & Concepts
FurinBiologyPseudorabiesVirologyGlycoproteinViral replicationViral entryVirusCell biologyMolecular biologyBiochemistryEnzymeHerpesvirus Infections and TreatmentsToxin Mechanisms and ImmunotoxinsVector-Borne Animal Diseases